Molecular basis for the mechanism of action of an anti-TACE antibody

Inhibitors of tumor necrosis factor-α converting enzyme (TACE) have potential as therapeutics for various diseases. Many small molecule inhibitors, however, exhibit poor specificity profiles because they target the highly conserved catalytic cleft of TACE. We report for the first time the molecular...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Peng, Li, Cook, Kimberly, Xu, Linda, Cheng, Li, Damschroder, Melissa, Gao, Changshou, Wu, Herren, Dall'Acqua, William F.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098442/
https://ncbi.nlm.nih.gov/pubmed/27610476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1226716
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