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Molecular basis for the antagonistic activity of an anti-CXCR4 antibody
Antagonistic antibodies targeting the G-protein C-X-C chemokine receptor 4 (CXCR4) hold promising therapeutic potential in various diseases. We report for the first time the detailed mechanism of action at a molecular level of a potent anti-CXCR4 antagonistic antibody (MEDI3185). We characterized th...
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| Publicado no: | MAbs |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966504/ https://ncbi.nlm.nih.gov/pubmed/26514996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1113359 |
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