Molecular basis for the antagonistic activity of an anti-CXCR4 antibody

Antagonistic antibodies targeting the G-protein C-X-C chemokine receptor 4 (CXCR4) hold promising therapeutic potential in various diseases. We report for the first time the detailed mechanism of action at a molecular level of a potent anti-CXCR4 antagonistic antibody (MEDI3185). We characterized th...

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Bibliografiska uppgifter
I publikationen:MAbs
Huvudupphovsmän: Peng, Li, Damschroder, Melissa M., Cook, Kimberly E., Wu, Herren, Dall'Acqua, William F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966504/
https://ncbi.nlm.nih.gov/pubmed/26514996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1113359
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