SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity

The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activation of transcription factors. It remains unknown how Nkx2.5 is deacetylated and how Nkx2....

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Vydáno v:Sci Rep
Hlavní autoři: Tang, Xiaoqiang, Ma, Han, Han, Lei, Zheng, Wei, Lu, Yun-Biao, Chen, Xiao-Feng, Liang, Shu-Ting, Wei, Gong-Hong, Zhang, Zhu-Qin, Chen, Hou-Zao, Liu, De-Pei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098195/
https://ncbi.nlm.nih.gov/pubmed/27819261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36576
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