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SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity
The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activation of transcription factors. It remains unknown how Nkx2.5 is deacetylated and how Nkx2....
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098195/ https://ncbi.nlm.nih.gov/pubmed/27819261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36576 |
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