Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Chemical strategies to using small molecules to stimulate hypoxia inducible factors (HIFs) activity and trigger a hypoxic response under normoxic conditions, such as iron chelators and inhibitors of prolyl hydroxylase domain (PHD) enzymes, have broad-spectrum activities and off-target effects. Here...

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Bibliografiske detaljer
Udgivet i:	Nat Commun
Main Authors:	Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2016
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5097156/ https://ncbi.nlm.nih.gov/pubmed/27811928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13312
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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

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