RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.

بواسطة Frost, Julianty, Ciulli, Alessio, Rocha, Sonia
الحاوية / القاعدة Wellcome Open Res (2019)

Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein

بواسطة Frost, Julianty, Rocha, Sonia, Ciulli, Alessio
الحاوية / القاعدة J Biol Chem (2021)

Roles of HIF and 2-Oxoglutarate-Dependent Dioxygenases in Controlling Gene Expression in Hypoxia

بواسطة Frost, Julianty, Frost, Mark, Batie, Michael, Jiang, Hao, Rocha, Sonia
الحاوية / القاعدة Cancers (Basel) (2021)

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S...

بواسطة Soares, Pedro, Gadd, Morgan S., Frost, Julianty, Galdeano, Carles, Ellis, Lucy, Epemolu, Ola, Rocha, Sonia, Read, Kevin D., Ciulli, Alessio
الحاوية / القاعدة J Med Chem (2017)

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

بواسطة Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio
الحاوية / القاعدة Nat Commun (2016)