Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Παρόμοια τεκμήρια

• Von Hippel–Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein
  ανά: Frost, Julianty, κ.ά.
  Έκδοση: (2021)
• Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
  ανά: Frost, Julianty, κ.ά.
  Έκδοση: (2016)
• RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. [version 1; referees: 2 approved]
  ανά: Julianty Frost, κ.ά.
  Έκδοση: (2019-01-01)
• 3,3,4,4-Tetra­fluoro-1-[2-(3,3,4,4-tetra­fluoro­pyrrolidin-1-yl)phen­yl]pyrrolidine
  ανά: Wang, Jin, κ.ά.
  Έκδοση: (2011)
• RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
  ανά: Frost, Julianty, κ.ά.
  Έκδοση: (2019)