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HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
Hypoxia-inducible factor-1α (HIF-1α)(1) is a global transcriptional regulator of the hypoxic response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor-suppressor protein (VHL), a component of an E3 ubiquitin ligase complex. This interaction thereby promotes the rapid d...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55503/ https://ncbi.nlm.nih.gov/pubmed/11504942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181341498 |
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