The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined. Here, we have demonstrated that the pseudokinase mixed lineage kinase domain–like protein...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Günther, Claudia, He, Gui-Wei, Kremer, Andreas E., Murphy, James M., Petrie, Emma J., Amann, Kerstin, Vandenabeele, Peter, Linkermann, Andreas, Poremba, Christopher, Schleicher, Ulrike, Dewitz, Christin, Krautwald, Stefan, Neurath, Markus F., Becker, Christoph, Wirtz, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096909/
https://ncbi.nlm.nih.gov/pubmed/27756058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87545
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