The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined. Here, we have demonstrated that the pseudokinase mixed lineage kinase domain–like protein...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Günther, Claudia, He, Gui-Wei, Kremer, Andreas E., Murphy, James M., Petrie, Emma J., Amann, Kerstin, Vandenabeele, Peter, Linkermann, Andreas, Poremba, Christopher, Schleicher, Ulrike, Dewitz, Christin, Krautwald, Stefan, Neurath, Markus F., Becker, Christoph, Wirtz, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096909/
https://ncbi.nlm.nih.gov/pubmed/27756058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87545
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