Cognate HLA absence in trans diminishes human NK cell education

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA(–) tumor ce...

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Udgivet i:J Clin Invest
Main Authors: Landtwing, Vanessa, Raykova, Ana, Pezzino, Gaetana, Béziat, Vivien, Marcenaro, Emanuela, Graf, Claudine, Moretta, Alessandro, Capaul, Riccarda, Zbinden, Andrea, Ferlazzo, Guido, Malmberg, Karl-Johan, Chijioke, Obinna, Münz, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096830/
https://ncbi.nlm.nih.gov/pubmed/27571408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86923
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