Cognate HLA absence in trans diminishes human NK cell education

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA(–) tumor ce...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Landtwing, Vanessa, Raykova, Ana, Pezzino, Gaetana, Béziat, Vivien, Marcenaro, Emanuela, Graf, Claudine, Moretta, Alessandro, Capaul, Riccarda, Zbinden, Andrea, Ferlazzo, Guido, Malmberg, Karl-Johan, Chijioke, Obinna, Münz, Christian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096830/
https://ncbi.nlm.nih.gov/pubmed/27571408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86923
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