Cognate HLA absence in trans diminishes human NK cell education

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA(–) tumor ce...

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發表在:J Clin Invest
Main Authors: Landtwing, Vanessa, Raykova, Ana, Pezzino, Gaetana, Béziat, Vivien, Marcenaro, Emanuela, Graf, Claudine, Moretta, Alessandro, Capaul, Riccarda, Zbinden, Andrea, Ferlazzo, Guido, Malmberg, Karl-Johan, Chijioke, Obinna, Münz, Christian
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096830/
https://ncbi.nlm.nih.gov/pubmed/27571408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86923
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