Cognate HLA absence in trans diminishes human NK cell education

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA(–) tumor ce...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Landtwing, Vanessa, Raykova, Ana, Pezzino, Gaetana, Béziat, Vivien, Marcenaro, Emanuela, Graf, Claudine, Moretta, Alessandro, Capaul, Riccarda, Zbinden, Andrea, Ferlazzo, Guido, Malmberg, Karl-Johan, Chijioke, Obinna, Münz, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096830/
https://ncbi.nlm.nih.gov/pubmed/27571408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86923
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