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TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections

Suppression of CD8 and CD4 T cells is a hallmark in chronic viral infections, including hepatitis C and HIV. While multiple pathways are known to inhibit CD8 T cells, the host molecules that restrict CD4 T cell responses are less understood. Here, we used inducible and CD4 T cell–specific deletion o...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lewis, Gavin M., Wehrens, Ellen J., Labarta-Bajo, Lara, Streeck, Hendrik, Zuniga, Elina I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096797/
https://ncbi.nlm.nih.gov/pubmed/27599295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87041
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