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TGF-β Signaling in T cells is Essential for CD8 T Cell Suppression and Viral Persistence In Vivo
Although deficient CD8 T cell responses have long been associated with chronic viral infections, the underlying mechanisms are still unclear. Here we report that enhanced and sustained TGF-β/Smad signaling is a distinctive feature of virus-specific CD8 T cells during chronic versus acute viral infec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3039716/ https://ncbi.nlm.nih.gov/pubmed/19604493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.06.015 |
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