DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine. An HIV-derived conserved element (CE) p24(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant res...

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Detalles Bibliográficos
Publicado en:J Immunol
Main Authors: Hu, Xintao, Valentin, Antonio, Dayton, Frances, Kulkarni, Viraj, Alicea, Candido, Rosati, Margherita, Chowdhury, Bhabadeb, Gautam, Rajeev, Broderick, Kate E., Sardesai, Niranjan Y., Martin, Malcolm A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Formato: Artigo
Idioma:Inglês
Publicado: AAI 2016
Assuntos:
Immunotherapy and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096510/
https://ncbi.nlm.nih.gov/pubmed/27733554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600697
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