DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine. An HIV-derived conserved element (CE) p24(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant res...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Hu, Xintao, Valentin, Antonio, Dayton, Frances, Kulkarni, Viraj, Alicea, Candido, Rosati, Margherita, Chowdhury, Bhabadeb, Gautam, Rajeev, Broderick, Kate E., Sardesai, Niranjan Y., Martin, Malcolm A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Format: Artigo
Sprog:Inglês
Udgivet: AAI 2016
Fag:
Immunotherapy and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096510/
https://ncbi.nlm.nih.gov/pubmed/27733554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600697
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