DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine. An HIV-derived conserved element (CE) p24(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant res...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Hu, Xintao, Valentin, Antonio, Dayton, Frances, Kulkarni, Viraj, Alicea, Candido, Rosati, Margherita, Chowdhury, Bhabadeb, Gautam, Rajeev, Broderick, Kate E., Sardesai, Niranjan Y., Martin, Malcolm A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2016
Soggetti:
Immunotherapy and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096510/
https://ncbi.nlm.nih.gov/pubmed/27733554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600697
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