DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting variable regions of the HIV proteome are hurdles in the development of an effective AIDS vaccine. An HIV-derived conserved element (CE) p24(gag) plasmid DNA (pDNA) vaccine is able to redirect immunodominant res...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Hu, Xintao, Valentin, Antonio, Dayton, Frances, Kulkarni, Viraj, Alicea, Candido, Rosati, Margherita, Chowdhury, Bhabadeb, Gautam, Rajeev, Broderick, Kate E., Sardesai, Niranjan Y., Martin, Malcolm A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Format: Artigo
Langue:Inglês
Publié: AAI 2016
Sujets:
Immunotherapy and Vaccines
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096510/
https://ncbi.nlm.nih.gov/pubmed/27733554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600697
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