HIV-1 p24(gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice

Viral diversity is considered a major impediment to the development of an effective HIV-1 vaccine. Despite this diversity, certain protein segments are nearly invariant across the known HIV-1 Group M sequences. We developed immunogens based on the highly conserved elements from the p24(gag) region a...

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Autori principali: Kulkarni, Viraj, Rosati, Margherita, Valentin, Antonio, Ganneru, Brunda, Singh, Ashish K., Yan, Jian, Rolland, Morgane, Alicea, Candido, Beach, Rachel Kelly, Zhang, Gen-Mu, Le Gall, Sylvie, Broderick, Kate E., Sardesai, Niranjan Y., Heckerman, David, Mothe, Beatriz, Brander, Christian, Weiner, David B., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610668/
https://ncbi.nlm.nih.gov/pubmed/23555935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060245
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