Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27(Gag) and HIV-1 Env and found that priming vacci...

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Dades bibliogràfiques
Publicat a:Hum Vaccin Immunother
Autors principals: Hu, Xintao, Lu, Zhongyan, Valentin, Antonio, Rosati, Margherita, Broderick, Kate E., Sardesai, Niranjan Y., Marx, Preston A., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6183272/
https://ncbi.nlm.nih.gov/pubmed/29939820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2018.1489949
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