Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs

BACKGROUND: Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, we report...

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Gepubliceerd in:Reprod Biol Endocrinol
Hoofdauteurs: Kang, Jung-Taek, Cho, Bumrae, Ryu, Junghyun, Ray, Caitlin, Lee, Eun-Jin, Yun, Yun-Jin, Ahn, SunMi, Lee, JinSeok, Ji, Dal-Young, Jue, Nathaniel, Clark-Deener, Sherrie, Lee, Kiho, Park, Kwang-Wook
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095964/
https://ncbi.nlm.nih.gov/pubmed/27809915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-016-0206-5
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