Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos

BACKGROUND: The CRISPR/Cas9 system can effectively introduce site-specific modifications to the genome. The efficiency is high enough to induce targeted genome modifications during embryogenesis, thus increasing the efficiency of producing genetically modified animal models and having potential clin...

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Dades bibliogràfiques
Publicat a:BMC Biotechnol
Autors principals: Carey, Kayla, Ryu, Junghyun, Uh, Kyungjun, Lengi, Andrea J., Clark-Deener, Sherrie, Corl, Benjamin A., Lee, Kiho
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501304/
https://ncbi.nlm.nih.gov/pubmed/31060546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0517-7
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