Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos

BACKGROUND: The CRISPR/Cas9 system can effectively introduce site-specific modifications to the genome. The efficiency is high enough to induce targeted genome modifications during embryogenesis, thus increasing the efficiency of producing genetically modified animal models and having potential clin...

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Detaylı Bibliyografya
Yayımlandı:BMC Biotechnol
Asıl Yazarlar: Carey, Kayla, Ryu, Junghyun, Uh, Kyungjun, Lengi, Andrea J., Clark-Deener, Sherrie, Corl, Benjamin A., Lee, Kiho
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501304/
https://ncbi.nlm.nih.gov/pubmed/31060546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0517-7
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