Frequency of off-targeting in genome edited pigs produced via direct injection of the CRISPR/Cas9 system into developing embryos

BACKGROUND: The CRISPR/Cas9 system can effectively introduce site-specific modifications to the genome. The efficiency is high enough to induce targeted genome modifications during embryogenesis, thus increasing the efficiency of producing genetically modified animal models and having potential clin...

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Veröffentlicht in:BMC Biotechnol
Hauptverfasser: Carey, Kayla, Ryu, Junghyun, Uh, Kyungjun, Lengi, Andrea J., Clark-Deener, Sherrie, Corl, Benjamin A., Lee, Kiho
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501304/
https://ncbi.nlm.nih.gov/pubmed/31060546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0517-7
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