Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

Application of genetically engineered (GE) large animals carrying multi-allelic modifications has been hampered by low efficiency in production and extended gestation period compared to rodents. Here, we rapidly generated RAG2/IL2RG double knockout pigs using direct injection of CRISPR/Cas9 system i...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Lei, Shaohua, Ryu, Junghyun, Wen, Ke, Twitchell, Erica, Bui, Tammy, Ramesh, Ashwin, Weiss, Mariah, Li, Guohua, Samuel, Helen, Clark-Deener, Sherrie, Jiang, Xi, Lee, Kiho, Yuan, Lijuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846862/
https://ncbi.nlm.nih.gov/pubmed/27118081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25222
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi