Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency

Application of genetically engineered (GE) large animals carrying multi-allelic modifications has been hampered by low efficiency in production and extended gestation period compared to rodents. Here, we rapidly generated RAG2/IL2RG double knockout pigs using direct injection of CRISPR/Cas9 system i...

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Udgivet i:Sci Rep
Main Authors: Lei, Shaohua, Ryu, Junghyun, Wen, Ke, Twitchell, Erica, Bui, Tammy, Ramesh, Ashwin, Weiss, Mariah, Li, Guohua, Samuel, Helen, Clark-Deener, Sherrie, Jiang, Xi, Lee, Kiho, Yuan, Lijuan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846862/
https://ncbi.nlm.nih.gov/pubmed/27118081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25222
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