In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

Current protocols for hematopoietic stem/progenitor cell (HSPC) gene therapy, involving the transplantation of ex vivo genetically modified HSPCs are complex and not without risk for the patient. We developed a new approach for in vivo HSPC transduction that does not require myeloablation and transp...

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Foilsithe in:Blood
Main Authors: Richter, Maximilian, Saydaminova, Kamola, Yumul, Roma, Krishnan, Rohini, Liu, Jing, Nagy, Eniko-Eva, Singh, Manvendra, Izsvák, Zsuzsanna, Cattaneo, Roberto, Uckert, Wolfgang, Palmer, Donna, Ng, Philip, Haworth, Kevin G., Kiem, Hans-Peter, Ehrhardt, Anja, Papayannopoulou, Thalia, Lieber, André
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2016
Ábhair:
Gene Therapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095755/
https://ncbi.nlm.nih.gov/pubmed/27554082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-711580
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