A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice

We recently reported on an in vivo hematopoietic stem cell (HSC) gene therapy approach. It involves the subcutaneous injections of G-CSF/AMD3100 to mobilize HSCs from the bone marrow into the peripheral blood stream and the intravenous injection of an integrating helper-dependent adenovirus vector s...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Wang, Hongjie, Richter, Maximilian, Psatha, Nikoletta, Li, Chang, Kim, Jiho, Liu, Jing, Ehrhardt, Anja, Nilsson, Susan K., Cao, Benjamin, Palmer, Donna, Ng, Philip, Izsvák, Zsuzsanna, Haworth, Kevin G., Kiem, Hans-Peter, Papayannopoulou, Thalia, Lieber, André
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722719/
https://ncbi.nlm.nih.gov/pubmed/29255741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.11.004
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