Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are resistant to conventional cytotoxic drugs, inhibition of autophagy represents a promising therapeutic strategy in clinical oncology. We previously...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Autophagy and Cell Death
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094956/
https://ncbi.nlm.nih.gov/pubmed/27248168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9601
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