Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are resistant to conventional cytotoxic drugs, inhibition of autophagy represents a promising therapeutic strategy in clinical oncology. We previously...

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Vydáno v:Oncotarget
Hlavní autoři: Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper: Autophagy and Cell Death
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094956/
https://ncbi.nlm.nih.gov/pubmed/27248168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9601
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