Sorafenib-induced defective autophagy promotes cell death by necroptosis

Autophagy is one of the main cytoprotective mechanisms that cancer cells deploy to withstand the cytotoxic stress and survive the lethal damage induced by anti-cancer drugs. However, under specific conditions, autophagy may, directly or indirectly, induce cell death. In our study, treatment of the A...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kharaziha, Pedram, Chioureas, Dimitris, Baltatzis, George, Fonseca, Pedro, Rodriguez, Patricia, Gogvadze, Vladimir, Lennartsson, Lena, Björklund, Ann-Charlotte, Zhivotovsky, Boris, Grandér, Dan, Egevad, Lars, Nilsson, Sten, Panaretakis, Theocharis
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research paper: Autophagy and Cell Death
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741916/
https://ncbi.nlm.nih.gov/pubmed/26416459
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