Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immun...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chan, Anissa S. H., Jonas, Adria Bykowski, Qiu, Xiaohong, Ottoson, Nadine R., Walsh, Richard M., Gorden, Keith B, Harrison, Ben, Maimonis, Peter J., Leonardo, Steven M., Ertelt, Kathleen E., Danielson, Michael E., Michel, Kyle S., Nelson, Mariana, Graff, Jeremy R., Patchen, Myra L., Bose, Nandita
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094785/
https://ncbi.nlm.nih.gov/pubmed/27812183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165909
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