Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immun...

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Vydáno v:PLoS One
Hlavní autoři: Chan, Anissa S. H., Jonas, Adria Bykowski, Qiu, Xiaohong, Ottoson, Nadine R., Walsh, Richard M., Gorden, Keith B, Harrison, Ben, Maimonis, Peter J., Leonardo, Steven M., Ertelt, Kathleen E., Danielson, Michael E., Michel, Kyle S., Nelson, Mariana, Graff, Jeremy R., Patchen, Myra L., Bose, Nandita
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094785/
https://ncbi.nlm.nih.gov/pubmed/27812183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165909
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