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P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain

P-glycoprotein (PgP), a drug efflux pump in blood–brain barrier endothelial cells, is a major clinical obstacle for effective central nervous system drug delivery. Identifying PgP regulatory pathways that can be exploited clinically is critical for improving central nervous system drug delivery. We...

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Detalles Bibliográficos
Publicado en:J Cereb Blood Flow Metab
Main Authors: Tome, Margaret E, Herndon, Joseph M, Schaefer, Charles P, Jacobs, Leigh M, Zhang, Yifeng, Jarvis, Chelsea K, Davis, Thomas P
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094312/
https://ncbi.nlm.nih.gov/pubmed/27466374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16661728
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