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P-glycoprotein trafficking as a therapeutic target to optimize CNS drug delivery

The primary function of the blood-brain barrier (BBB) /neurovascular unit is to protect the CNS from potentially harmful xenobiotic substances and maintain CNS homeostasis. Restricted access to the CNS is maintained via a combination of tight junction proteins as well as a variety of efflux and infl...

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Detalhes bibliográficos
Publicado no:Adv Pharmacol
Main Authors: Davis, Thomas P., Sanchez-Covarubias, Lucy, Tome, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301584/
https://ncbi.nlm.nih.gov/pubmed/25307213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.apha.2014.06.009
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