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PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE BLOOD BRAIN BARRIER: P-glycoprotein and occludin trafficking as therapeutic targets to optimize CNS drug delivery
The blood-brain barrier (BBB) is a physical and metabolic barrier that separates the CNS from the peripheral circulation. CNS drug delivery across the BBB is challenging, primarily due to the physical restriction of paracellular diffusion between the endothelial cells that comprise the microvessels...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851303/ https://ncbi.nlm.nih.gov/pubmed/23138008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.231/JIM.0b013e318276de79 |
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