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PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE BLOOD BRAIN BARRIER: P-glycoprotein and occludin trafficking as therapeutic targets to optimize CNS drug delivery

The blood-brain barrier (BBB) is a physical and metabolic barrier that separates the CNS from the peripheral circulation. CNS drug delivery across the BBB is challenging, primarily due to the physical restriction of paracellular diffusion between the endothelial cells that comprise the microvessels...

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Podrobná bibliografie
Hlavní autoři: McCaffrey, Gwen, Davis, Thomas P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851303/
https://ncbi.nlm.nih.gov/pubmed/23138008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.231/JIM.0b013e318276de79
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