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P-glycoprotein trafficking at the blood–brain barrier altered by peripheral inflammatory hyperalgesia
P-glycoprotein (ABCB1/MDR1, EC 3.6.3.44), the major efflux transporter at the blood–brain barrier (BBB), is a formidable obstacle to CNS pharmacotherapy. Understanding the mechanism(s) for increased P-glycoprotein activity at the BBB during peripheral inflammatory pain is critical in the development...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851298/ https://ncbi.nlm.nih.gov/pubmed/22716933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07831.x |
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