Acetaminophen Modulates P-Glycoprotein Functional Expression at the Blood-Brain Barrier by a Constitutive Androstane Receptor–Dependent Mechanism

Effective pharmacologic treatment of pain with opioids requires that these drugs attain efficacious concentrations in the central nervous system (CNS). A primary determinant of CNS drug permeation is P-glycoprotein (P-gp), an endogenous blood-brain barrier (BBB) efflux transporter that is involved i...

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Main Authors: Slosky, Lauren M., Thompson, Brandon J., Sanchez-Covarrubias, Lucy, Zhang, Yifeng, Laracuente, Mei-Li, Vanderah, Todd W., Ronaldson, Patrick T., Davis, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807077/
https://ncbi.nlm.nih.gov/pubmed/24019224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.086298
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