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Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery
The blood–brain barrier (BBB) is the most significant obstacle to effective CNS drug delivery. It possesses structural and biochemical features (i.e., tight-junction protein complexes and, influx and efflux transporters) that restrict xenobiotic permeation. Pathophysiological stressors (i.e., periph...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3313594/ https://ncbi.nlm.nih.gov/pubmed/22468221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.11.67 |
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