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Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery

The blood–brain barrier (BBB) is the most significant obstacle to effective CNS drug delivery. It possesses structural and biochemical features (i.e., tight-junction protein complexes and, influx and efflux transporters) that restrict xenobiotic permeation. Pathophysiological stressors (i.e., periph...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ronaldson, Patrick T, Davis, Thomas P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313594/
https://ncbi.nlm.nih.gov/pubmed/22468221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.11.67
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