NAMPT-mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice

Obesity is associated with adipose tissue dysfunction and multi-organ insulin resistance. However, the mechanisms of such obesity-associated systemic metabolic complications are not clear. Here, we characterized mice with adipocyte-specific deletion of nicotinamide phosphoribosyltransferase (NAMPT),...

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Publicado en:Cell Rep
Main Authors: Stromsdorfer, Kelly L., Yamaguchi, Shintaro, Yoon, Myeong Jin, Moseley, Anna C., Franczyk, Michael P., Kelly, Shannon C., Qi, Nathan, Imai, Shin-ichiro, Yoshino, Jun
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094180/
https://ncbi.nlm.nih.gov/pubmed/27498863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.027
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