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Humanized mouse xenograft models: narrowing the tumor-microenvironment gap

Cancer research has long been hampered by the limitations of the current model systems. Both cultured cells and mouse xenografts grow in an environment highly dissimilar to that of their originating tumor, frequently resulting in promising treatments that are ultimately clinically ineffective. The d...

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Vydáno v:Cancer Res
Hlavní autoři: Morton, J. Jason, Bird, Gregory, Refaeli, Yosef, Jimeno, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093075/
https://ncbi.nlm.nih.gov/pubmed/27587540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1260
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