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The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.

Although crucial to mucosal vaccine development, the mechanisms of defense against mucosal viral infection are still poorly understood. Protection, cytotoxic T lymphocytes (CTL), and neutralizing antibodies have all been observed, but cause and effect have been difficult to determine. The ability of...

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Udgivet i:J Clin Invest
Principais autores: Belyakov, I M, Ahlers, J D, Brandwein, B Y, Earl, P, Kelsall, B L, Moss, B, Strober, W, Berzofsky, J A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509161/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9854042/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5102
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