The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.

Although crucial to mucosal vaccine development, the mechanisms of defense against mucosal viral infection are still poorly understood. Protection, cytotoxic T lymphocytes (CTL), and neutralizing antibodies have all been observed, but cause and effect have been difficult to determine. The ability of...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Belyakov, I M, Ahlers, J D, Brandwein, B Y, Earl, P, Kelsall, B L, Moss, B, Strober, W, Berzofsky, J A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509161/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9854042/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI5102
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