Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse.

Cholestasis is associated with hypercholesterolemia and appearance of the abnormal lipoprotein X (LpX) in plasma. Using mice with a disrupted Mdr2 gene, we tested the hypothesis that LpX originates as a biliary lipid vesicle. Mdr2-deficient mice lack Mdr2 P-glycoprotein, the canalicular translocator...

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Publicado en:	J Clin Invest
Autores principales:	Elferink, R P, Ottenhoff, R, van Marle, J, Frijters, C M, Smith, A J, Groen, A K
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1998
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC509123/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9802889/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI3597
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