Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis

BACKGROUND: Carboxyl-ester lipase (CEL) contributes to fatty acid ethyl ester metabolism, which is implicated in alcoholic pancreatitis. The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11. Variation in this VNTR has been linked to monogenic pancreatic disease, while c...

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Fjeld, Karianne, Beer, Sebastian, Johnstone, Marianne, Zimmer, Constantin, Mössner, Joachim, Ruffert, Claudia, Krehan, Mario, Zapf, Christian, Njølstad, Pål Rasmus, Johansson, Stefan, Bugert, Peter, Miyajima, Fabio, Liloglou, Triantafillos, Brown, Laura J., Winn, Simon A., Davies, Kelly, Latawiec, Diane, Gunson, Bridget K., Criddle, David N., Pirmohamed, Munir, Grützmann, Robert, Michl, Patrick, Greenhalf, William, Molven, Anders, Sutton, Robert, Rosendahl, Jonas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
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Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5089759/
https://ncbi.nlm.nih.gov/pubmed/27802312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165567
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