A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

Carboxyl-ester lipase is a digestive pancreatic enzyme encoded by the highly polymorphic CEL gene(1). Mutations in CEL cause maturity-onset diabetes of the young (MODY) with pancreatic exocrine dysfunction(2). Here we identified a hybrid allele (CEL-HYB), originating from a crossover between CEL and...

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Publicado no:Nat Genet
Main Authors: Fjeld, Karianne, Weiss, Frank Ulrich, Lasher, Denise, Rosendahl, Jonas, Chen, Jian-Min, Johansson, Bente B., Kirsten, Holger, Ruffert, Claudia, Masson, Emmanuelle, Steine, Solrun J., Bugert, Peter, Cnop, Miriam, Grützmann, Robert, Mayerle, Julia, Mössner, Joachim, Ringdal, Monika, Schulz, Hans-Ulrich, Sendler, Matthias, Simon, Peter, Sztromwasser, Paweł, Torsvik, Janniche, Scholz, Markus, Tjora, Erling, Férec, Claude, Witt, Heiko, Lerch, Markus M., Njølstad, Pål R., Johansson, Stefan, Molven, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321495/
https://ncbi.nlm.nih.gov/pubmed/25774637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3249
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