Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.

Insulin-dependent diabetes mellitus in humans is linked with specific HLA class II genes, e.g., HLA-DQA1*0301/ DQB1*0302 (DQ8). To investigate the roles of HLA-DQ8 molecules and glutamic acid decarboxylase (GAD) in disease development, we generated DQ8(+)/I-Abo transgenic mice expressing functional...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wen, L, Wong, F S, Burkly, L, Altieri, M, Mamalaki, C, Kioussis, D, Flavell, R A, Sherwin, R S
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508960/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9727063/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI2723
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