Pivotal role of α2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease

Reduced smooth muscle (SM)‐specific α2 Na(+) pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM‐α2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Physiol
Egile Nagusiak: Blaustein, Mordecai P., Chen, Ling, Hamlyn, John M., Leenen, Frans H. H., Lingrel, Jerry B., Wier, W. Gil, Zhang, Jin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Topical review
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088234/
https://ncbi.nlm.nih.gov/pubmed/27350568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272419
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