Pivotal role of α2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease

Reduced smooth muscle (SM)‐specific α2 Na(+) pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM‐α2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension...

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Detalles Bibliográficos
Publicado en:J Physiol
Main Authors: Blaustein, Mordecai P., Chen, Ling, Hamlyn, John M., Leenen, Frans H. H., Lingrel, Jerry B., Wier, W. Gil, Zhang, Jin
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Topical review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088234/
https://ncbi.nlm.nih.gov/pubmed/27350568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272419
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