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Pivotal role of α2 Na(+) pumps and their high affinity ouabain binding site in cardiovascular health and disease
Reduced smooth muscle (SM)‐specific α2 Na(+) pump expression elevates basal blood pressure (BP) and increases BP sensitivity to angiotensin II (Ang II) and dietary NaCl, whilst SM‐α2 overexpression lowers basal BP and decreases Ang II/salt sensitivity. Prolonged ouabain infusion induces hypertension...
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| Veröffentlicht in: | J Physiol |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5088234/ https://ncbi.nlm.nih.gov/pubmed/27350568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272419 |
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