Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome

Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive therapeutic options against oncological targets, especially upon functionalization with an alkylating agent such as seco-CBI. These molecules also provide an alternative for oncogenes deemed “undruggable” at the prote...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lin, Jason, Hiraoka, Kiriko, Watanabe, Takayoshi, Kuo, Tony, Shinozaki, Yoshinao, Takatori, Atsushi, Koshikawa, Nobuko, Chandran, Anandhakumar, Otsuki, Joe, Sugiyama, Hiroshi, Horton, Paul, Nagase, Hiroki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087912/
https://ncbi.nlm.nih.gov/pubmed/27798693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165581
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