Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death

The 24(S)-hydroxycholesterol (24S-OHC), which plays an important role in maintaining brain cholesterol homeostasis, has been shown to possess neurotoxicity. We have previously reported that 24S-OHC esterification by ACAT1 and the resulting lipid droplet (LD) formation are responsible for 24S-OHC-ind...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Lipid Res
Autores principales: Takabe, Wakako, Urano, Yasuomi, Vo, Diep-Khanh Ho, Shibuya, Kimiyuki, Tanno, Masaki, Kitagishi, Hiroaki, Fujimoto, Toyoshi, Noguchi, Noriko
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2016
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087868/
https://ncbi.nlm.nih.gov/pubmed/27647838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M068775
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares